NAD⁺ Therapy
1. What Is NAD⁺ and Why Does It Decline?
Nicotinamide adenine dinucleotide (NAD⁺) is a co-enzyme found in every living cell. It powers the electron-transport chain that turns food into ATP, switches on longevity proteins called sirtuins, and repairs DNA after oxidative damage. Starting in our mid-20s, NAD⁺ levels fall 8-10 % per decade, starving mitochondria and accelerating fatigue, weight gain, and cognitive slowdown. Restoring the NAD⁺ pool—via intravenous infusions or precursor molecules such as NMN and NR—can rewind many of those age-related losses. PMCNew York Post
2. How NAD⁺ Therapy Works
- Cellular Energy Surge – Higher NAD⁺ revs mitochondrial output, translating to greater stamina and metabolic rate. puredropiv.com
- Metabolic Re-Programming – Activates sirtuin and AMPK pathways that improve insulin sensitivity and promote fat oxidation. PMC
- DNA & Neuro-Repair – Fuels PARP enzymes that fix DNA strands and supports neuronal resilience, sharpening focus and mood. ScienceDirect
- Inflammation Control – Dampens NF-κB signalling, lowering systemic inflammation that drives chronic disease and weight-loss resistance. aestheticsmedspa.com
3. Evidence Snapshot
- Oral NR Trials – Daily 300 mg nicotinamide riboside raised blood NAD⁺ ~60 % in eight weeks with excellent tolerability. PMC
- Systems-Approach Supplement (2023 Nature study) – Multi-pathway product boosted whole-blood NAD⁺ significantly above standard NR alone. Nature
- Weight-Management Clinics – Emerging case reports show IV NAD⁺ improves resting metabolic rate and reduces appetite in overweight adults; formal RCTs are under way. cloveroxygen.comivnutrition.com
- Quality-of-Life Meta-analysis (2024 PubMed) – Oral NADH lowered anxiety, heart-rate and inflammatory cytokines with a low adverse-event profile. PubMed
Note: Large-scale human trials are still limited; current data are early-phase or mechanistic.
4. Ideal Candidate Profile
- Persistent fatigue, brain fog, or slow workout recovery
- Stubborn weight despite diet and exercise
- Bio-hackers seeking longevity or healthy aging
- Post-illness or post-surgery patients needing mitochondrial recharge
- Contra-indications: active cancer, uncontrolled gout, severe kidney disease, pregnancy or breastfeeding
Not sure you qualify? Our complimentary telehealth screen gives clarity in minutes.
5. Your Valley Weight Loss NAD⁺ Roadmap
Day 0 – Virtual Consult
• 15-minute video visit, review goals, medications, recent labs
Week 1 – Baseline Metrics
• Comprehensive metabolic panel, CRP, HbA1c, and NAD⁺ precursor baseline
Week 2 – Infusion Kick-Off
• 500-750 mg NAD⁺ intravenous drip over 2-3 hours in-clinic
• Guided breathwork and hydration protocols to minimize flushing or nausea
Weeks 2-6 – Loading Phase
• Weekly IVs or every-other-day mini-pushes (250 mg) for intensive replenishment
• Daily oral NMN/NR stack to sustain intracellular pools
Months 2-12 – Optimization & Maintenance
• Monthly IV “top-ups” or high-dose sublingual precursors
• Lifestyle layering: intermittent fasting, resistance training, and GLP-1 coaching
Beyond 12 Months – Cycling
• 6-week on / 6-week off schedule or seasonal intensives based on energy, weight and lab markers
6. Safety and Side-Effect Management
Most individuals feel only mild warmth, slight chest pressure, or light nausea during the first 20 minutes of an infusion—symptoms that ease when the drip is slowed and hydration is encouraged. Rare reports include headache, flushing, or GI upset with high-dose oral NMN/NR. We run kidney-function labs every six months and adjust protocols immediately if adverse signals appear. Effect DoctorsPubMed
7. Frequently Asked Questions
How fast will I notice benefits?
Many clients feel a clear “mental snap” and energy lift within 24 hours of the first infusion; metabolic and weight-loss changes surface over 4-6 weeks.
IV vs. oral—do I need both?
IV delivers immediate, high cellular saturation; oral precursors maintain levels between drips. We typically combine them for the first two months, then reassess.
Will NAD⁺ help me lose weight directly?
It optimizes mitochondrial efficiency and insulin sensitivity, making fat-loss efforts more effective—especially when stacked with GLP-1 or peptide programs.
Is this therapy FDA-approved?
NAD⁺ itself is classified as Generally Recognized As Safe (GRAS) as a nutrient; IV use is off-label but widely employed in functional-medicine and addiction-recovery settings. All compounding pharmacies we use are FDA-registered 503B facilities.
8. Why Choose Valley Weight Loss?
- Board-Certified Metabolic Experts guiding every infusion cycle
- On-Site Lab & Recovery Lounge with medical-grade massage chairs and red-light therapy add-ons
- Synergistic Programs—stack NAD⁺ with GLP-1, peptides, IV antioxidants, and body-contouring for exponential results
- Data-Driven Tracking—monthly VO₂-max, body-composition, and cognitive-performance metrics
9. Ready to Recharge Your Cells?
Click “Book My Free Consultation” or call (956) 540-2160. Experience the science-backed reboot that elite athletes, CEOs, and longevity researchers swear by—exclusively at Valley Weight Loss.
